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Model mouse Product List and Ranking from 4 Manufacturers, Suppliers and Companies | IPROS GMS

Model mouse Product List

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Human-type model animal

Human-type model animal

We will create mice and rats with drug metabolism similar to that of humans!

We have created human-like drug metabolism model mice and rats equipped with artificial chromosome vectors carrying human drug metabolism-related genes. By administering new drugs, we can predict safety for humans, leading to accelerated pharmaceutical development and reduced costs. 【Features】 ■ Improved prediction of safety for humans ■ Accelerated pharmaceutical development and increased success rates ■ Lower costs for new drug development and reduced national healthcare burden *For more details, please refer to the catalog or feel free to contact us.

  • Other experimental equipment
  • Model mouse

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Ultra First (3 weeks) NASH screening mouse model

Ultra First (3 weeks) NASH screening mouse model

Physiogenex has developed a method for NASH screening that can be implemented in three weeks. The control drugs are ezetimibe and liraglutide.

A test system has been developed by Physiogenex using a unique method (using cyclodextrin, as described later) that allows for the extremely rapid induction of NASH within just three weeks. This model uses 8-week-old male mice and measures parameters such as ALT, AST, liver weight as a percentage of body weight, total cholesterol, triglycerides, and fatty acids, all of which increase within just three weeks (at 11 weeks of age). It also shows an increase in the NAS score (indicators: steatosis, inflammation, fibrosis, ballooning, total score) and significant liver inflammation and fibrosis. Treatment with ezetimibe (5 mg/kg) for two weeks results in a decrease in plasma total cholesterol and liver fat, a reduction in gene expression related to inflammation and fibrosis, and a lower overall NAFLD score due to decreased liver inflammation. Similarly, treatment with liraglutide for two weeks also shows a reduction in body weight and liver weight, as well as a lower overall NAS score due to decreased liver inflammation. For more details, please contact us. *Inquiries can also be made through our website. We will respond promptly. (Search for "Clea Japan" at http://www.clea-japan.com/)

  • Other Contract Life Science Specialization
  • Model mouse

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"Arthritis model" CIA model CAIA model

"Arthritis model" CIA model CAIA model

Stress-free rearing under advanced microbiological control is essential for the stability of the system. Our company is capable of producing high-quality autoimmune disease models!

We would like to introduce the "Arthritis Model" that we handle. In the production of autoimmune disease models, stress-free breeding under advanced microbiological control is essential for system stability. Furthermore, providing appropriate care for symptoms is also important for maintaining the health of the mice. Our company is capable of producing high-quality autoimmune disease models through advanced breeding management techniques and meticulous attention to the disease state. [Features] ■ Advanced breeding management techniques ■ Meticulous attention to the disease state ■ Capability to produce high-quality autoimmune disease models *For more details, please refer to the PDF materials or feel free to contact us.

  • Animal cells
  • Model mouse

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Graft-versus-host disease (GvHD)

Graft-versus-host disease (GvHD)

We will introduce the transplantation and anatomical results of the "acute GvHD model" and "chronic GvHD model."

We would like to introduce the production of model mice/rats for "graft-versus-host disease (GvHD)" that we are conducting. The "acute GvHD model," which is a dangerous complication in bone marrow transplantation, is created by transplanting donor spleen cells into recipient mice, while the "chronic GvHD model" induces symptoms similar to lupus nephritis. Please feel free to contact us for more details. 【Model Examples】 ■ Acute GvHD Model ■ Chronic GvHD Model *For more information, please refer to the PDF document or feel free to contact us.

  • Animal cells
  • Model mouse

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秋田大学・名古屋大学技術：遺伝性対側性色素異常症疾患モデルマウス

秋田大学・名古屋大学技術：遺伝性対側性色素異常症疾患モデルマウス

希少色素性疾患治療薬のスクリーニングツール​

遺伝性対側性色素異常症（DSH）は、両手背・両足背に色素斑と白斑がまだら模様に出現する色素性疾患である。DSHは致死性疾患ではないものの、外見の変化により患者に精神的な負担を生じさせることがある。しかし、現時点では有効な治療法は確立されていない。​ 　ヒトにおけるDSHの病因遺伝子はAdar1と特定されているが、ヘテロ接合型Adar1ノックアウトマウスにはDSH様表現型が現れず、モデルマウスの作製は長年の課題であった。発明者らは、ヘテロ接合型Adar1ノックアウトマウスに特定の遺伝子を発現させる、または特定の物質を投与することで、DSH様表現型を示すことを見出した。さらに、メラノサイト特異的にAdar1をノックアウトすることで、通常は胚性致死となるホモ接合型Adar1ノックアウトマウスの作製にも成功し、同様にDSH様表現型を示すことを確認した。以上より、複数のアプローチによるDSH疾患モデルマウスの作製を達成した。本モデルマウスは、DSH治療薬のスクリーニングツールへの活用が期待される。​ A26-002

  • others
  • Model mouse

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Diet-induced NASH mouse model

Diet-induced NASH mouse model

Physiogenex's proprietary diet-induced (DIN) NASH mouse model. Evaluation of NASH drug efficacy in an obese and insulin-resistant environment.

The Physiogenex independently developed diet-induced NASH mouse model involves feeding a high-fat, high-cholesterol diet, along with the addition of fructose to drinking water. This induces severe liver damage, obesity, and insulin resistance. As a result, liver fat and hepatocyte ballooning appear by the 16th week of feeding, and severe liver complications (inflammation and fibrosis) develop by 25 weeks of age. Additionally, the administration of the FXR agonist obeticholic acid, which is related to NASH, results in observed reductions in obesity, insulin resistance, fatty liver, and ballooning at both 16 and 25 weeks of age. This experimental system allows for the efficacy evaluation of drugs using obeticholic acid as a control, set against a background of obesity and insulin resistance that resembles the histopathological features of human NASH. Furthermore, there are efficacy evaluation data and academic papers (PDF) using Elafibranor (GFT505) as a control drug. For more details, please contact us. *Inquiries can also be made through our website. We will respond promptly. (Search for "Clea Japan" at http://www.clea-japan.com/)

  • Other Contract Life Science Specialization
  • Model mouse

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